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Mixed anxiety and depressive disorder

MedGen UID:
572834
•Concept ID:
C0338908
•
Mental or Behavioral Dysfunction
Synonyms: Anxiety depression; anxiety depression; mixed anxiety and depressive disorder
SNOMED CT: Mixed anxiety and depressive disorder (231504006); Anxiety depression (231504006)
 
Monarch Initiative: MONDO:0041086

Professional guidelines

PubMed

Prevalence, psychosocial correlates and service utilization of depressive and anxiety disorders in Hong Kong: the Hong Kong Mental Morbidity Survey (HKMMS).
Lam LC, Wong CS, Wang MJ, Chan WC, Chen EY, Ng RM, Hung SF, Cheung EF, Sham PC, Chiu HF, Lam M, Chang WC, Lee EH, Chiang TP, Lau JT, van Os J, Lewis G, Bebbington P
Soc Psychiatry Psychiatr Epidemiol 2015 Sep;50(9):1379-88. Epub 2015 Feb 8 doi: 10.1007/s00127-015-1014-5. PMID: 25660760
Characteristics of effective collaborative care for treatment of depression: a systematic review and meta-regression of 74 randomised controlled trials.
Coventry PA, Hudson JL, Kontopantelis E, Archer J, Richards DA, Gilbody S, Lovell K, Dickens C, Gask L, Waheed W, Bower P
PLoS One 2014;9(9):e108114. Epub 2014 Sep 29 doi: 10.1371/journal.pone.0108114. PMID: 25264616Free PMC Article
Mixed anxiety and depressive disorder outcomes: prospective cohort study in primary care.
Walters K, Buszewicz M, Weich S, King M
Br J Psychiatry 2011 Jun;198(6):472-8. doi: 10.1192/bjp.bp.110.085092. PMID: 21628709

Recent clinical studies

Etiology

Efficacy of Silexan in patients with anxiety disorders: a meta-analysis of randomized, placebo-controlled trials.
Dold M, Bartova L, Volz HP, Seifritz E, Möller HJ, Schläfke S, Kasper S
Eur Arch Psychiatry Clin Neurosci 2023 Oct;273(7):1615-1628. Epub 2023 Jan 30 doi: 10.1007/s00406-022-01547-w. PMID: 36717399Free PMC Article
The relevance of 'mixed anxiety and depression' as a diagnostic category in clinical practice.
Möller HJ, Bandelow B, Volz HP, Barnikol UB, Seifritz E, Kasper S
Eur Arch Psychiatry Clin Neurosci 2016 Dec;266(8):725-736. Epub 2016 Mar 22 doi: 10.1007/s00406-016-0684-7. PMID: 27002521Free PMC Article
Prevalence, psychosocial correlates and service utilization of depressive and anxiety disorders in Hong Kong: the Hong Kong Mental Morbidity Survey (HKMMS).
Lam LC, Wong CS, Wang MJ, Chan WC, Chen EY, Ng RM, Hung SF, Cheung EF, Sham PC, Chiu HF, Lam M, Chang WC, Lee EH, Chiang TP, Lau JT, van Os J, Lewis G, Bebbington P
Soc Psychiatry Psychiatr Epidemiol 2015 Sep;50(9):1379-88. Epub 2015 Feb 8 doi: 10.1007/s00127-015-1014-5. PMID: 25660760
Mixed anxiety and depressive disorder outcomes: prospective cohort study in primary care.
Walters K, Buszewicz M, Weich S, King M
Br J Psychiatry 2011 Jun;198(6):472-8. doi: 10.1192/bjp.bp.110.085092. PMID: 21628709
Defining anxious depression: going beyond comorbidity.
Silverstone PH, von Studnitz E
Can J Psychiatry 2003 Nov;48(10):675-80. doi: 10.1177/070674370304801006. PMID: 14674050

Diagnosis

Comparison of the Agreement and Accuracy Between Paramedic and Hospital Diagnosis.
Purabdollah M, Khorrami Markani A, Moghaddam Tabrizi F, Mokhtari M
Air Med J 2022 Mar-Apr;41(2):228-232. Epub 2021 Dec 6 doi: 10.1016/j.amj.2021.10.013. PMID: 35307148
The relevance of 'mixed anxiety and depression' as a diagnostic category in clinical practice.
Möller HJ, Bandelow B, Volz HP, Barnikol UB, Seifritz E, Kasper S
Eur Arch Psychiatry Clin Neurosci 2016 Dec;266(8):725-736. Epub 2016 Mar 22 doi: 10.1007/s00406-016-0684-7. PMID: 27002521Free PMC Article
Prevalence, psychosocial correlates and service utilization of depressive and anxiety disorders in Hong Kong: the Hong Kong Mental Morbidity Survey (HKMMS).
Lam LC, Wong CS, Wang MJ, Chan WC, Chen EY, Ng RM, Hung SF, Cheung EF, Sham PC, Chiu HF, Lam M, Chang WC, Lee EH, Chiang TP, Lau JT, van Os J, Lewis G, Bebbington P
Soc Psychiatry Psychiatr Epidemiol 2015 Sep;50(9):1379-88. Epub 2015 Feb 8 doi: 10.1007/s00127-015-1014-5. PMID: 25660760
Mixed anxiety and depressive disorder outcomes: prospective cohort study in primary care.
Walters K, Buszewicz M, Weich S, King M
Br J Psychiatry 2011 Jun;198(6):472-8. doi: 10.1192/bjp.bp.110.085092. PMID: 21628709
Defining anxious depression: going beyond comorbidity.
Silverstone PH, von Studnitz E
Can J Psychiatry 2003 Nov;48(10):675-80. doi: 10.1177/070674370304801006. PMID: 14674050

Therapy

Efficacy of Silexan in patients with anxiety disorders: a meta-analysis of randomized, placebo-controlled trials.
Dold M, Bartova L, Volz HP, Seifritz E, Möller HJ, Schläfke S, Kasper S
Eur Arch Psychiatry Clin Neurosci 2023 Oct;273(7):1615-1628. Epub 2023 Jan 30 doi: 10.1007/s00406-022-01547-w. PMID: 36717399Free PMC Article
Beneficial effects of Silexan on co-occurring depressive symptoms in patients with subthreshold anxiety and anxiety disorders: randomized, placebo-controlled trials revisited.
Bartova L, Dold M, Volz HP, Seifritz E, Möller HJ, Kasper S
Eur Arch Psychiatry Clin Neurosci 2023 Feb;273(1):51-63. Epub 2022 Mar 9 doi: 10.1007/s00406-022-01390-z. PMID: 35262795Free PMC Article
Efficacy of Silexan in mixed anxiety-depression--A randomized, placebo-controlled trial.
Kasper S, Volz HP, Dienel A, Schläfke S
Eur Neuropsychopharmacol 2016 Feb;26(2):331-340. Epub 2015 Dec 12 doi: 10.1016/j.euroneuro.2015.12.002. PMID: 26718792
Impulsiveness in chronic hepatitis C patients.
Fábregas BC, Abreu MN, Dos Santos AK, Moura AS, Carmo RA, Teixeira AL
Gen Hosp Psychiatry 2014 May-Jun;36(3):261-5. Epub 2013 Dec 24 doi: 10.1016/j.genhosppsych.2013.12.006. PMID: 24456821
Defining anxious depression: going beyond comorbidity.
Silverstone PH, von Studnitz E
Can J Psychiatry 2003 Nov;48(10):675-80. doi: 10.1177/070674370304801006. PMID: 14674050

Prognosis

Comparison of the Agreement and Accuracy Between Paramedic and Hospital Diagnosis.
Purabdollah M, Khorrami Markani A, Moghaddam Tabrizi F, Mokhtari M
Air Med J 2022 Mar-Apr;41(2):228-232. Epub 2021 Dec 6 doi: 10.1016/j.amj.2021.10.013. PMID: 35307148
The relevance of 'mixed anxiety and depression' as a diagnostic category in clinical practice.
Möller HJ, Bandelow B, Volz HP, Barnikol UB, Seifritz E, Kasper S
Eur Arch Psychiatry Clin Neurosci 2016 Dec;266(8):725-736. Epub 2016 Mar 22 doi: 10.1007/s00406-016-0684-7. PMID: 27002521Free PMC Article
Characteristics of effective collaborative care for treatment of depression: a systematic review and meta-regression of 74 randomised controlled trials.
Coventry PA, Hudson JL, Kontopantelis E, Archer J, Richards DA, Gilbody S, Lovell K, Dickens C, Gask L, Waheed W, Bower P
PLoS One 2014;9(9):e108114. Epub 2014 Sep 29 doi: 10.1371/journal.pone.0108114. PMID: 25264616Free PMC Article
Mixed anxiety and depressive disorder outcomes: prospective cohort study in primary care.
Walters K, Buszewicz M, Weich S, King M
Br J Psychiatry 2011 Jun;198(6):472-8. doi: 10.1192/bjp.bp.110.085092. PMID: 21628709
Sibling risk of anxiety disorders based on hospitalizations in Sweden.
Li X, Sundquist J, Sundquist K
Psychiatry Clin Neurosci 2011 Apr;65(3):233-8. doi: 10.1111/j.1440-1819.2011.02199.x. PMID: 21507129

Clinical prediction guides

Efficacy of Silexan in patients with anxiety disorders: a meta-analysis of randomized, placebo-controlled trials.
Dold M, Bartova L, Volz HP, Seifritz E, Möller HJ, Schläfke S, Kasper S
Eur Arch Psychiatry Clin Neurosci 2023 Oct;273(7):1615-1628. Epub 2023 Jan 30 doi: 10.1007/s00406-022-01547-w. PMID: 36717399Free PMC Article
Efficacy of Silexan in mixed anxiety-depression--A randomized, placebo-controlled trial.
Kasper S, Volz HP, Dienel A, Schläfke S
Eur Neuropsychopharmacol 2016 Feb;26(2):331-340. Epub 2015 Dec 12 doi: 10.1016/j.euroneuro.2015.12.002. PMID: 26718792
Impulsiveness in chronic hepatitis C patients.
Fábregas BC, Abreu MN, Dos Santos AK, Moura AS, Carmo RA, Teixeira AL
Gen Hosp Psychiatry 2014 May-Jun;36(3):261-5. Epub 2013 Dec 24 doi: 10.1016/j.genhosppsych.2013.12.006. PMID: 24456821
Mixed anxiety and depressive disorder outcomes: prospective cohort study in primary care.
Walters K, Buszewicz M, Weich S, King M
Br J Psychiatry 2011 Jun;198(6):472-8. doi: 10.1192/bjp.bp.110.085092. PMID: 21628709
Distress and functioning in mixed anxiety and depressive disorder.
Małyszczak K, Pawłowski T
Psychiatry Clin Neurosci 2006 Apr;60(2):168-73. doi: 10.1111/j.1440-1819.2006.01482.x. PMID: 16594940

Recent systematic reviews

Characteristics of effective collaborative care for treatment of depression: a systematic review and meta-regression of 74 randomised controlled trials.
Coventry PA, Hudson JL, Kontopantelis E, Archer J, Richards DA, Gilbody S, Lovell K, Dickens C, Gask L, Waheed W, Bower P
PLoS One 2014;9(9):e108114. Epub 2014 Sep 29 doi: 10.1371/journal.pone.0108114. PMID: 25264616Free PMC Article

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